Exploring the innovation and creative processes through interdisciplinary work and research structures. Understanding design problems independent from their disciplinary boundaries. Gaining an integrative understanding of innovation based on human-centered design.
Explores the relationships between medicine, healthcare practices, the human body, and visual culture from Ancient Mesopotamia to present day Turkey. An introduction to visual medical and health humanities, the human condition is examined using diverse works of art drawn from different eras, geographies, stylistic and cultural movements. Develops skills of critical observation, description, and creativity by studying works from the history of art that highlight medicine, healing, and healthcare.
Historical intersections of music and politics. Music and lyrics against the political historical background of select countries from all continents. Music for political propaganda and protest.
Introduction to Law; Public Law; Private Law; Introduction to Turkish Law (Turkish Judicial System; Constitutional Law; Administrative Law; Criminal Law; Criminal Procedure) History of Turkish Private Law; Basic Concepts of Private Law; Law of Persons; Law of Contracts; Sales Contracts; Law of Torts; Law of Property; Business Enterprises; Negotiable Instrument; Secured Transactions; Corporate Law; Corporate Taxation; Competition Law; Intellectual Property Law; International Commercial Arbitration; Labour Law.
Fundamental biology and hallmarks of cancer. Genomics of cancer, uncontrolled cell division, cell cycle,angiogenesis, metastasis, evasion of apoptosis, immune evasion, genomic instability, targeted cancer therapies and current developments in cancer. Weekly literature discussions.
Micro and nanoscale biological systems and their applications in regenerative medicine, disease modeling, diagnostics and therapy. Properties of micro and nanoscale building blocks, their assembly processes and their use in synthesizing larger systems to address biological problems. A plethora of biological and chemical structures, design of systems for use in sensing and diagnosing biological phenomena, manipulating cell functions, engineering tissues, modeling pathologies and delivering therapeutics. Bioinspired and biomimetic design of microphysiological systems, tissues and organ-on-a-chip approaches. Technological impact and use of such systems in translational research.
Applied aspects of molecular biology. Introduction and explanation of what is molecular biotechnology as a scientific discipline, which tools of recombinant DNA technologies are applied, and industrial microbiology. The development of molecular biotechnology, DNA, RNA, and protein synthesis, recombinant DNA technology, chemical synthesis, amplification, and sequencing of DNA, bioinformatics, genomics and proteomics, heterologous protein production in eukaryotic cells, directed mutagenesis and protein engineering, protein therapeutics, nucleic acids as therapeutic agents, vaccines, synthesis of commercial products by recombinant microorganisms, transgenic animals, molecular biotechnology and society.
Mechanisms by which cells respond to external physical forces (tension, compression, shear, pressure) and relevant signaling processes involved in development, regeneration and pathology (i.e. cancer); mechanisms of cell-matrix interactions and physical stimuli-mediated cellular processes such as tissue remodeling. Cell cytoskeleton and mechanics, ECM and cell-matrix interactions, cellular responses to external physical stimuli, cellular responses to external physical stimuli, mechanobiology in development, mechanobiology in regeneration and tissue remodeling, mechanobiology in disease, analysis of cell mechanics, Manipulation of cell mechanics, applications of mechanobiology.
Biochemical changes in mitochondrial diseases metabolism, alteration of certain enzyme activities, shuttles, biochemical mitochondrial markers. Mitochondria, role of Mitochondria in metabolism, role of mitochondria in energy metabolism, mitochondria and aging, mitochondria and oxidative stress, mitochondria and cell death, guidelines on experimental methods on mitochondria, mitochondrial diseases, manuscript and Review presentation.
Study of molecular mechanisms of autophagy regulation in health and disease. The basic mechanisms of autophagy and contribution of autophagy abnormalities to disease formation, progression and drug responses. Introduction to autophagy, Molecular mechanisms-I: ULK1/2, ATG13, ATG9 complexes, Molecular mechanisms-II: Beclin 1 complexes, Molecular mechanisms-III: Omegasome complexes, Molecular mechanisms-IV: ATG8/LC3 conjugation systems, Molecular mechanisms-V: Selective autophagy and receptors, Molecular mechanisms-VI: Autolysosomes, Molecular mechanisms-VII: mTOR and AMPK pathways, Autophagy and cancer, Autophagy and neurodegeneration, Autophagy and rare diseases, Autophagy and infection, Autophagy and immunity.
Multidisciplinary approach to the diagnosis of cardiovascular diseases: Mechanisms of diseases, pathologic findings, clinical presentations, laboratory tests, diagnostic imaging and treatment. Topics include heart failure, congenital heart disease, ischemic heart disease, valvular heart disease, cardiomyopathies, hypertension and hypertensive heart disease, pericardial disease and heart tumors, atherosclerosis and non-atherosclerotic vascular diseases.
Basic concepts of chemical and biological engineering systems. Modeling through material and energy balances. Problem solving methods, computational techniques and computer simulation. Examples from chemical and pharmaceutical industries.
Protein characterization, enzyme kinetics, basic metabolic pathways, membrane structure and function, biochemistry of energy and signal transduction, replication and expressions of genes. Labaratory studies.
Characteristics of fluids, fluid statics, Bernoulli equation, fluid kinematics, boundary layers, viscous flows and turbulence.
Experimental demonstration of concepts taught in separations, reaction engineering and control.
Chemical process and product design methods; economic analysis of chemical processing plants.
Examine the technologies, environmental impacts and economics of main energy sources of today and tomorrow including fossil fuels, nuclear power, biomass, geothermal energy, hydropower, wind energy, and solar energy. Comparison of different energy systems within the context of sustainability. Hydrogen economy and fuel cells.
Adsorption on surfaces, structural and dynamic considerations in adsorption, thermodynamics of adsorption, methods for catalyst characterization, pore structure and surface area, surface chemistry of catalysis, metals, highly dispersed catalysts, industrial examples with emphasis on energy production
Crude oil and biomass refining technologies. Fractionation, catalytic- and thermo- cracking, gasoline and diesel upgrading and other side processes in crude oil refining; gasification, pyrolysis, transesterification and condensation processes in biomass refining; economical and environmental factors in refining.
Biotechnology course with a strong emphasis on bioprocess engineering principles. Fermentation, mammalian cell culture, continuous culture, biological unit operations, lectures on synthetic biology topics. Strongly recommended for CHBI students that wish to design a biological process in CHBI 491.
Reconstruction of metabolic network from genome information and its structural and functional analysis, computational models of biochemical reaction networks; system biology in drug discovery and proteomics, flux balance analysis; modeling of gene expression; system biology in artificial intelligence.
Fundamental principles and advantages of drug delivery technologies; drug delivery mechanisms; advantages of controlled delivery; administration routes; drug delivery agents; possible modifications of delivery vehicles for specific applications.
A capstone design course where students apply engineering and science knowledge in a chemical and biological engineering design project. Development, design and management of a project in teams under realistic constraints and conditions. Emphasis on communication, teamwork and presentation skills.